- s.p.l.i.t (PC)
- Sabre Wulf (Spectrum)
- Sakura Wars (Saturn)
- Samba De Amigo (Dreamcast)
- Samurai Shodown (3DO)
- Samurai Shodown! 2 (NGPC)
- Sasquatchers (Playdate)
- Saturday Edition (Playdate)
- Saturn Bomberman (Saturn)
- Savage (Amstrad)
- Seaman (Dreamcast)
- Sega Bass Fishing (Dreamcast)
- Sega Rally 2 (Dreamcast)
- Sega Rally Championship (Saturn)
- Sega Worldwide Soccer '98 (Saturn)
- Segagaga (Dreamcast)
- Sensible World of Soccer '96/'97 (Amiga)
- Shadow Gadget & Shining Gadget (Playdate)
- Shadow Squadron (32X)
- Shadowgate PD (Playdate)
- Shenmue (Dreamcast)
- Shift (Playdate)
- Shift II (Playdate)
- Shining Force CD (SCD)
- Shining Force III (Saturn)
- Shining The Holy Ark (Saturn)
- Shining Wisdom (Saturn)
- Shinobi Legions (Saturn)
- Shinrei Jusatsushi Tarōmaru (Saturn)
- Ship Shape (Playdate)
- Sid Meier's Pirates! (C64)
- Silhouette Mirage (Saturn)
- Silpheed (SCD)
- Simon the Sorcerer (Amiga)
- Sketch, Share, Solve (Playdate)
- Skew (Playdate)
- Skies Of Arcadia (Dreamcast)
- Skool Daze (Spectrum)
- Skwish (Playdate)
- Skyhammer (Jaguar)
- Slitherlink PD (Playdate)
- Smolitaire (Playdate)
- Snak (Playdate)
- Snatcher (SCD)
- SNK Gals' Fighters (NGPC)
- SNK vs. Capcom: Card Fighter's Clash (NGPC)
- SNK vs. Capcom: Card Fighter's Clash 2 Expand Edition (NGPC)
- SNK vs. Capcom: Match of the Millennium (NGPC)
- Snoik! (Playdate)
- Soko (Playdate)
- Solar Descent (Playdate)
- Solomon's Key (Amstrad)
- Sonic Adventure 2 (Dreamcast)
- Sonic Jam (Saturn)
- Sonic R (Saturn)
- Sonic the Hedgehog Pocket Adventure (NGPC)
- Sorcerian (PC-88)
- Sorcery (Amstrad)
- Soukyugurentai (Saturn)
- Soulcalibur (Dreamcast)
- Sound Mind (Playdate)
- Space Channel 5 (Dreamcast)
- Space Harrier (32X)
- Space Hulk: Vengeance of the Blood Angels (3DO)
- Space Invaders (2600)
- Space Invaders XL (Nuon)
- Space Master (Playdate)
- Spacerat Miner (Playdate)
- Sparrow Solitaire (Playdate)
- Speedball (PC)
- Speedball 2: Brutal Deluxe (Amiga)
- Spellcorked! (Playdate)
- Spike II: The Great Emu War (Playdate)
- Spindizzy (Amstrad)
- Sporestory (Playdate)
- Star Control II (3DO)
- Star Cruiser (X68000)
- Star Raiders II (Atari8bit)
- Star Sled (Playdate)
- Star Wars Arcade (32X)
- Star Wars: Attack on the Death Star (X68000)
- Stardust (Amiga)
- Stars of the Screen (Playdate)
- Steam'd Roller (Playdate)
- Stellar Assault SS (Saturn)
- Street Fighter Alpha 2 (Saturn)
- Street Fighter III 3rd Strike: Fight for the Future (Dreamcast)
- Street Fighter Zero 3 (Saturn)
- Street Harrier (X68000)
- Sunsoft Collection 1 (Evercade)
- Sunsoft Collection 2 (Evercade)
- Super Burnout (Jaguar)
- Super Cars II (Amiga)
- Super Hexagon (Phone)
- Super ICARUS (Playdate)
- Super Street Fighter II Turbo (3DO)
- Super Street Fighter II: The New Challengers (X68000)
- Superfrog (Amiga)
- Swap Machina (Playdate)
- Switchblade (Amstrad)
- Syndicate (Amiga)